The CamSol Method Web Servers

(more info on the method)

  • Quantitative solubility ranking of protein variants (sequence-based).

  • Identification of aggregation hotspots on protein structure.

  • Rational design of protein variants with enhanced solubility. 


Free for academic users (registration/login required). Commercial users please contact Professor Michele Vendruscolo.

CamSol Intrinsic Sequence-based method of predicting protein solubility and generic aggregation propensity.
CamSol Structurally Corrected Structure-based method of calculating a solubility profile, which accounts for the proximity of the amino acids in the structure and for their solvent exposure. The structurally corrected profile can be color-coded on the structure of the protein to spot patches of low solubility that may elicit self-assembly.
CamSol design A method of rational design of protein variants with enhanced solubility (more info on the CamSol method)



P. Sormanni, F. A. Aprile and M. Vendruscolo. 
The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility. 
J. Mol. Biol. 2015. doi:10.1016/j.jmb.2014.09.026.

P. Sormanni, L. Amery, S. Ekizoglou, M. Vendruscolo, and B. Popovic.
Rapid and accurate in silico solubility screening of a monoclonal antibody library. 
Sci. Rep.  2017. doi:10.1038/s41598-017-07800-w.